1. Product Identification

• Product Name: β‑Methylnorleucine
• Synonyms: 3‑Methylnorleucine; (2S,3R)‑2‑Amino‑3‑methylhexanoic acid; 2‑Amino‑3‑methylhexanoic acid
• CAS Number: 28116‑92‑9
• Molecular Formula: C₇H₁₅NO₂
• Molecular Weight: 145.20 g/mol
• IUPAC Name: (2S,3R)‑2‑amino‑3‑methylhexanoic acid

2. Specifications

• Appearance: White to off‑white crystalline powder
• Purity: ≥98.0% (HPLC)
• Chiral Purity: ≥99.0% (for single enantiomer, e.g., 2S,3R)
• Melting Point: 218–222 °C (dec.)
• Solubility:
  • Soluble in: Water, methanol, dilute acids
  • Insoluble in: Hexane, ethyl acetate
• Moisture Content: ≤0.5%
• Residue on Ignition: ≤0.1%

3. Chemical & Physical Properties

• Density: ~1.07 g/cm³
• pKa: ~2.3 (COOH); ~9.7 (NH₂)
• Optical Rotation: [α]₂₀/D = +12° to +16° (c = 1, H₂O)
• Stability: Stable under ambient conditions; avoid strong oxidizing agents

4. Applications

• Research tool: Non‑natural amino acid for peptide synthesis and protein engineering
• Antimetabolite: Isoleucine antagonist; inhibits bacterial growth by blocking isoleucine biosynthesis
• Biochemical studies: Investigation of branched‑chain amino acid metabolism and enzyme mechanisms

5. Handling & Storage

• Storage: Store at ‑20 °C in a dry, sealed container; protect from light
• Handling: Use standard laboratory precautions; avoid inhalation, skin/eye contact